Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Clinical effect of neoadjuvant chemotherapy combined with laparoscopic surgery for patients with colorectal cancer

Hong-yan Ma¹, Yu-hui Zhou¹, Lian-zhong Gao², Li Wang², Jun-dong Du¹

¹Department of Surgery, Hebei Yanda Hospital, Hebei Langfang 065201, China; ²Department of Surgery, Sanhe Traditional Chinese Medicine Hospital, Hebei Langfang 065200, China.

For correspondence:- Jun-dong Du Email: dujundongi@163.com

Accepted: 26 November 2023 Published: 31 December 2023

Citation: Ma H, Zhou Y, Gao L, Wang L, Du J. Clinical effect of neoadjuvant chemotherapy combined with laparoscopic surgery for patients with colorectal cancer. Trop J Pharm Res 2023; 22(12):2511-2516 doi: 10.4314/tjpr.v22i12.13

© 2023 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To assess the clinical effect of neoadjuvant chemotherapy in combination with laparoscopic surgery in treating progressive colorectal cancer.

Methods: 90 patients with colorectal cancer admitted to Hebei Yanda Hospital, Hebei Langfang, China between December 2020 and December 2021 were enrolled. The patients were randomly grouped into control and study groups. Control group underwent laparoscopic surgery while the study group underwent neoadjuvant chemotherapy in addition to laparoscopic surgery. Gastrointestinal function recovery time, tumor control effect, tumor marker level, and adverse reactions were investigated and compared between the two groups.

Results: Time to anal exhaust, time to first defecation, time to first solid food intake, and time to recover to normal bowel sounds were earlier in the study group compared to control group (p < 0.05). Study group exhibited a greater overall rate of tumor control response., while the rate of tumor lymphatic metastasis was also significant (p < 0.05). After treatment, the study group exhibited significantly lower levels of tumor markers compared to control group (p < 0.05). The occurrence of adverse reactions was not significant between the two groups (p > 0.05).

Conclusion: Neoadjuvant chemotherapy in conjunction with laparoscopic surgery in the treatment of progressive rectal cancer improves patient outcomes and enhances prognosis.

Keywords: Colorectal cancer, Laparoscopic surgery, Neoadjuvant chemotherapy, Adverse effect